Quality by Design (QbD) is a systematic approach to development that begins with predefined objectives and emphasizes product and process understanding and process control. Achieving QbD requires an in-depth understanding of physicochemical properties.
Early identification of Critical Quality Attributes (CQA) of excipients and active pharmaceutical ingredients (API) and their impact on a formulation is a key component of QbD. Micromeritics’ instruments and contract analytical services offer solutions for the early identification of CQA’s, continuous process monitoring, and verification, which are the foundation of QbD. Historically, particle size has been the dominant physical characteristic control parameter for release. But now, properties such as surface morphology, porosity, particle shape, density, and surface energy are additionally utilized as predictive tools to reduce possible manufacturing failures by predicting scale-up effects on the final product.
High Resolution, High-throughput Physisorption and Chemisorption Instrument
Recognized as the most advanced instrument in the field for material surface characterization. The 3Flex has become a crucial tool for providing high resolution adsorption, desorption, isotherms to advance and validate fundamental understanding into development of methodologies and process improvements.
Gas pycnometry is recognized as one of the most reliable techniques for obtaining true, absolute, skeletal, and apparent volume and density. This technique is non-destructive as it uses the gas displacement method to measure volume. Inert gases, such as helium or nitrogen, are used as the displacement medium. Density calculations using the gas displacement method are much more accurate and reproducible than the traditional Archimedes water displacement method.
ASAP2020 Plus Chemisorption Option -Accelerated Surface area & Porosimetry System
The ASAP 2020 Plus Chemisorption option permits you to obtain valuable information about the physical and chemical properties of your catalyst, catalyst support, adsorbents, and other materials. Its unique design provides a high level of system cleanliness to permit low-pressure chemisorption isotherms.
Accelerated Surface Area and Porosimetry System – Sophisted Design, Intuitive Operation, Research-Grade Results:
The Micromeritics ASAP 2020 Plus integrates a variety of automated gas sorption techniques into a single, but powerful, table top instrument. The system is designed to provide high-quality surface area, porosity, and chemisorption isotherm data to materials analysis laboratories with ever-expanding analytical requirements.
AutoPore V – Mercury Intrusion Porosimetry
Class Leading, Proven Performance Establishing a New Benchmark for Operational Safety
The mercury porosimetry analysis technique is based on the intrusion of mercury into a porous structure under stringently controlled pressures. Besides offering speed, accuracy, and a wide measurement range, mercury porosimetry permits you to calculate numerous sample properties such as pore size distributions, total pore volume, total pore surface area, median pore diameter and sample densities (bulk and skeletal).
Well-known for its sophisticated high-end R&D systems, SEO expands its family of wettability measurement instruments to include a system suitable in Educational, QC, Product Development and multiple user applications.
SEO DCA 200 Series Analyzers
The SEO DCA series analyzer offer a powerful. And versatile approach to comprehensive understanding of the complex interaction at liquid-liquid and liquid-solid surfaces. Whether you need to improve adhesion, apply a coating, or modify a surface, a SEO DCA system provides the solution.
The information of surface or the interfacial tension is critically important in applications such as detergency and emulsification and is also important for many biological processes. Especially, the Du NÕuy Ring method and the Wihelmy Plate method are commonly used for measuring surface / interfacial tensions.
The DST A series are precise tension meters (with Digital LCD display) for the measurement of surface (Liquid – Vapour) & interfacial tensions (Liquid – Liquid) using both the Du NÕuy ring and the Wihelmy plate.
The DST M series is designed for Educational, Quality Control and other multiple user applications. By simply operating the sample stage manually, you can get the surface / interfacial tension results quickly with no additional calculations.
The FT4 Powder Rheometer – a universal powder flow tester for measuring powder flow properties and powder behaviour.
The FT4 was designed with one purpose in mind – to characterise the rheology of powders, or powder flow properties. This remains a primary function today, but the instrument, accessories and methodologies have been continuously developed to the point where the FT4 is now considered a universal powder flow tester.
Gemini VII 2390 Surface Area Analyzer
Unique Design – The secret of Gemini’s unique capabilities lies in the innovative use of sample and balance tubes. These tubes are identical in every aspect, including their thermal environment. The sample and reference reservoirs, like their associated tubes, are physically identical and are initially charged to the same pressure. During an analysis, differential pressure between reservoirs is monitored. This common mode technique assures that any differential pressure is solely due to adsorption by the sample and not to factors that lead to variations in free space during an analysis.
The GeoPyc employs a unique displacement measurement technique that uses Dry Flo, a quasi-fluid composed of small, rigid spheres having a high degree of flow-ability. The sample is placed in a bed of Dry Flo which is agitated and gently consolidated about the sample. The GeoPyc collects the displacement data, performs the calculations, and displays or prints the results.
The HPVA II Series of adsorption analyzers from Particulate Systems uses the static volumetric method to obtain high-pressure adsorption and desorption isotherms utilizing gases such as hydrogen, methane, and carbon dioxide. The volumetric technique consists of introducing [dosing] a known amount of gas [adsorptive] into the chamber containing the sample to be analyzed.
When the sample reaches equilibrium with the adsorbate gas, the final equilibrium pressure is recorded. These data are then used to calculate the quantity of gas adsorbed by the sample.
Developed as a direct and improved successor to the widely used Fisher Model 95 Subsieve Sizer (FSSS), the Micromeritics SAS II has improved the FSSS’s performance by offering easy-to-use automated functions together with electronically recorded data.
Sedigraph III Plus Particle Size Analyzer
The new SediGraph® III Plus determines particle size by using the highly accurate and reproducible sedimentation technique which measures the gravity-induced settling rates of different size particles in a liquid with known properties. This is simple yet extremely effective technique for providing particle size information for a wide variety of materials.
Dynamic Image/Particle Shape Analyzer
The SentinelPro is a class-leading dynamic image analyzer that is ideal for applications where particle shape, not just the particle size, may be critical information for predicting raw material quality and to maintain a high level of process control.
Particle morphology provides important information regarding the physical shape properties of your sample. It has been shown that shape can affect flowability, dispersion, packing density, segregation, aggregate formation, and microstructure character.
The fully automated SentinelPro is a well-suited research grade instrument or for use in a full production environment where speed, accuracy, and ease of use with its Pass/Fail shape control limits feature can be utilized.
Tristar II Plus Surface Area and porosity Instrument
Surface Area and Porosity Instrument
Analytical Versatility/ High Throughput/ Small Footprint
The TriStar II Plus is a an automated, three-station, surface area and porosity analyzer that delivers excellent performance and speed of analysis. With three available analysis ports, the TriStar II Plus provides high sample through-put and advanced data analysis features to the user. The unique stainless steel analysis manifold is corrosive resistant and designed for highly accurate gas management for confident and repeatable results.
Assess and Rank Powder Flowability
The Uniaxial Powder Tester (UPT) is a stand-alone uniaxial shear tester for simple, sensitive and cost effective powder characterisation. This powder flow tester delivers repeatable and reliable measurements, providing a robust alternative to traditional powder testing techniques.