Elzone II 5390

Micromeritics

Overview – Elzone II 5390: Particle Size Analyzer

Features

Superior Particle Sizing/Counting Capability in a Small Package

 

Elzone II Advantages

  • Counts and sizes organic and inorganic materials
  • Suitable for analyzing samples of mixed optical properties, densities, and shapes
  • Higher resolution than with other particle sizing methods
  • Low quantities of sample are analyzed accurately and easily
  • Compact size conserves laboratory bench-space
  • Plot overlays make comparing analysis results with those of product standards or other analysis results easy
  • Extensive statistical analysis and data presentation features included Liquids can be used without knowing viscosity or optical properties
  • A variety of conductive liquids can be used without knowing viscosity or optical properties
  • Does not require previous knowledge of sample properties (density, refractive index)
  • Plot overlays make comparing analysis results with those of product standards or other analysis results easy
  • Optional Confirm 21 CFR Part 11 software assists with compliance to FDA regulations. IQ and OQ services help assure that the system is validated for proper installation, accuracy, and consistent performance.

 

Ease of Use

  • Automatic start-up, run, and shut down routines
  • Automatic blockage detection and clearing
  • Automated flushing/rinsing
  • Automatic or manual calibration to accommodate different particle types and shapes


New Improved Design

  • No mercury manometer needed to perform concentration analysis
  • A grease-free connect/disconnect mechanism for the orifice tubes
  • A Faraday shield protects detector electronics from external sources of interference
  • Glassware from older Elzone models and certain Coulter Counter models can be used with the new Elzone II.
  1. Elzone II Particle Size Analyzer Applications

    Biological Materials – Biotech research depends on accurate measurements. Particle sizing of blood cells, platelets, bacteria, plant cells, mammalian cells, yeast, pollen, spores, and many other types of materials is typically done by population (number). Data collected are the number of cells per milliliter and/or the population distribution of cells. For example, these data can indicate to a researcher if a process adequately reduces the bacteria population in drinking water. Population data can also be used to evaluate fermentation processes.

    Abrasives – For an abrasive material to perform as specified, it is important that it have an appropriate size distribution with no particles above or below the intended size range. To make sure that each batch meets specifications, the sample must be analyzed as a volume (weight) and population (number) distribution. The volume distribution is used to ensure that the range and mean sizes are within specifications, and also that there are no over-sized particles in the sample.

    Toner and Inks – It is important that the particles have a narrow size distribution intoners or inks for printing. If there are any large particles, printer nozzles can clog or streaks can be left on prints. Both volume and population data are useful in analyzing toners and inks.

    Filtration – Population data illustrate how much material is being removed by a filter. Volume data will determine the minimum size particles the filter is capable of removing. Therefore, Elzone results can be used to determine how a filter is performing. This is useful for water treatment, beverage processing (beer, soft drinks, etc.), inject-ables (pharmaceuticals), pollution control, and many other filtration applications.

    Emulsions – Elzone results can be used to determine shelf life, proper emulsification, and droplet size of a wide variety of emulsions including pharmaceuticals, foods, and lubricants. Because the Elzone measures the volume of a particle, the data are little affected if the droplets change shape as they pass through the orifice tube.

  2. Elzone Particle ize Analyzer Software and Reports

    Superior Data Presentation Capability

    Data Reduction and Presentation

    • Off-line software allows the user to work with data or design analysis protocols without being at the instrument.
    • Capability to cut and paste data tables and export data as spreadsheet and ASCII files.
    • Plot overlays make it possible to compare analysis results directly with the results of product standards or other analysis results.
    • The new Elzone allows you to read, reduce, and report data obtained from a previous Elzone. Additionally, you have the capability to read and overlay data from the SediGraph and the Saturn DigiSizers, and to read text data files.
    • Compare data from other instruments by reading formatted text files or by manually entering information.
    • Elzone II is fully compatible with International Standard ISO13319 Determination of particle size distribution –Electrical sensing zone method.

    Confirm Software for the Elzone

    The optional Confirm software addresses FDA’s 21 CFR Part 11 requirements for submitting documentation in electronic form. Its features include assuring data security, maintenance of time-stamped audit trails, authority checks, password aging, and data reporting. You can rest assured that we have provided you with all of the features and tools necessary to maintain compliance with the highest level of data integrity possible. Service includes verification of instrument calibration and a comprehensive test of the complete system using established conditions and reference materials. If your company needs record-keeping and validation capabilities, Confirm software makes it extremely useful across all industries. It’s a great way for all companies to keep track of their data and provide verification of their analyses.

    Software Example 1

    Simultaneous analysis of 5 mono-disperse latex standards – Standards such as these are used to calibrate diameters determined using the Elzone II. Here the high degree of size resolution possible with the Elzone II is illustrated.

  3. Technique Overview

    Elzone Particle Size Analyzer Technique Overview

    Electrical Sensing Zone Method

    The Elzone uses the electrical sensing zone method (Coulter principle) of particle measurement. One advantageous characteristic of this measurement technique that differentiates it from the laser light scattering method is that Elzone data are unaffected by samples that have mixed optical properties, colors, and shapes. Furthermore, samples composed of materials having different densities also can be measured accurately. Particle size determination is dependent only on the volume of electrolyte displaced by a particle as it flows through the sensing zone.

    Another advantage of this technique is that the size distribution is determined by analyzing, one at a time, each particle from a representative subset of the introduced sample quantity. This particle-by-particle analysis technique provides accurate particle count data and, when combined with Micromeritics’ precision volume metering option, provides accurate number concentration data.

    Sensitivity as it relates to particle size analysis is the ability to detect small changes in the amount of material at a given size.This ability is very important to processes where a few particles either larger than or smaller than the bulk of the population is critical. As examples, a few large abrasive particles can leave deep gouges in a finished surface and a few small particles of chromatography packing materials can increase back pressure. The Elzone is sensitive to small quantities of over-sized and undersized particles in a given sample.

    The sample (a dry powder, paste, or emulsion) is dispersed at low concentration in an electrolyte solution. This dispersion is placed in a sample cup that also contains an electrode. A closed end glass tube is immersed in the dispersion. In the side of this tube and below the liquid surface is a precision hole (orifice) and within the glass tube is a second electrode. Applying a partial vacuum to the tube interior causes the dispersion to be drawn through the orifice forming a conductive path between the electrodes.

    The small diameter of the orifice, its short path length, and the dilute dispersion assures that for the great majority of the time particles pass through the orifice one at a time. Each particle while in the orifice displaces a volume of electrolyte equal to its own volume. Displacement of the electrolyte impedes the current flow between the electrodes and produces an electrical pulse, the amplitude of which is proportional to the particle volume. The Elzone counts the pulses and sorts them by amplitude and pulse width. This provides the data from which is calculated the particle population.

     

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